Jordan Grafman, Karen Thompson, Herbert Weingartner, Rick Martinez, and others
Script generation as an indicator of knowledge representation
in patients with Alzheimer's disease

Brain & Language 40. 3 (Apr 1991): 344-358


Examined script and lexical retrieval in 29 patients (mean age 64.07 yrs) with probable dementia of the Alzheimer's type (DAT), 14 matched depressed patients, and 31 matched normal controls. DAT Subjects' breakdown in script production was structurally similar to their impaired lexical retrieval such that script events of low frequency and low centrality value were lost first. DAT Subjects also produced more events that fell outside the script boundary and more event-order errors. Four cases with DAT were identified on the basis of Z scores whose script production was at least 2 standard deviations greater than their lexical production or vice versa. This finding suggests that it may be possible to dissociate script and lexical knowledge and production processes. Findings lend partial support for a model of knowledge representation that includes parallel and partially redundant memory networks that are distinctly distributed in the brain.


Maintained by Francis F. Steen, Communication Studies, University of California Los Angeles